‘Hard To Lose’ Mutations In Tumors May Predict Response To Immunotherapy

Cancer experts have tried, sometimes unsuccessfully, to use the total number of mutations in a tumor, called the tumor mutation burden (TMB), to predict a patient’s response to immunotherapy. Now, Johns Hopkins investigators have found that a subset of mutations within the overall TMB, termed “persistent mutations,” are less likely to be edited out as cancer evolves, rendering tumors more likely to respond to immunotherapy. Read more here.